Carbon Mesh Supported Thin Film Microextraction Membrane as a Means to Lower the Detection Limits of Benchtop and Portable GC/MS Instrumentation
Overview:
- A carbon mesh supported DVB/PDMS loaded thin film microextraction membrane was prepared which could be coupled to GC-MS techniques for highly sensitive analysis.
- Membranes exhibited substantially less bleed (background) than previous TFME designs with the ability to easily resolve any background peaks from analyte compounds.
- Exhibit an approximate factor of 24 X to 100 x (pre-equilibrium vs equilibrium) signal improvement/extraction amount when compared to commercially available 65 µm DVB/PDMS SPME fibers.
- Withstand agitation rates exceeding 3000 rpm in water allowing for accelerated extraction kinetics.
- By use of appropriate high volume desorption modules, TFME was coupled to benchtop and portable GC-MS instrumentation for targeted and untargeted analyses alike.
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| TF-SPME holder showing 6 replicate membranes simultaneously |
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Simplified attachment of TF-SPME device to a power drill for simple on-site agitation
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Comparative extraction efficiencies for a McReynolds headspace standard from various sorbent phases including 1: a 65 µm DVB/PDMS SPME fiber, 2: a 2 cm PDMS SBSE, 3: A DVB/PDMS TF-SPME device, 4: A HLB/PDMS TF-SPME device using suspension polymerization, 5: A HLB/PDMS TF-SPME using commercial HLB 6: HLB/PDMS TF-SPME using 1.33 µm homemade HLB particles
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Detection limits for select pesticides from surface waters using various extraction methodologies |
References:
[1] J.J. Grandy, E. Boyaci, J. Pawliszyn, Development of a Carbon Mesh Supported Thin Film Microextraction Membrane As a Means to Lower the Detection Limits of Benchtop and Portable GC/MS Instrumentation, Anal. Chem. 88 (2016). doi:10.1021/acs.analchem.5b04008.
[2] H. Piri-Moghadam, E. Gionfriddo, A. Rodriguez-Lafuente, J.J. Grandy, H.L. Lord, T. Obal, J. Pawliszyn, Inter-laboratory validation of a thin film microextraction technique for determination of pesticides in surface water samples, Anal. Chim. Acta. 964 (2017) 74–84. doi:10.1016/j.aca.2017.02.014.