Standard Gas Generating Vials


Overview:

A highly reproducible in-vial standard gas generating system was developed and validated for eventual application in quality control and standardization of GC-MS instrumentation. 

  • Vials prepared with a silicone oil/XAD-4 based sorbent proved to better retain the standard and were hence decided as the ideal choice for further vial development
  • Validation was performed on both GC-MS and GC-FID instrumentation using a modified McReynolds mixture
  • Vials were tested for intra/inter-batch reproducibility, storage stability, and depletion rate
  • Similar PFPH, PFBB, NEM, n-alkanes, carboxylic acids, aldehydes and BTEX, based vials have been produced
  




Comparison of inter-vial and inter-batch reproducibility

Inter-vial reproducibility of McReynolds standard gas generating vials when 1-minute extractions were performed at 35oC with a DVB/PDMS fiber


Compounds
Benzene
2-Pentanone
1-Nitropropane
Pyridine
1-Pentanol
Octane
Fvial
0.85
0.28
0.30
0.72
0.11
0.29
Fcrit
3.11
% RSD
3.4
3.5
3.3
3.8
3.7
3.4

        ANOVA verified that vials prepared from different batches of spiked pump oil were statistically identical at a 95% level of confidence

Vial Validation: Analyte depletion after multiple headspace extractions

Demonstration of less than 3.3% depletion for all analytes after 208 consecutive extractions were performed for 1 minute at 35 C using a DVB/CAR/PDMS fiber

References:

1: J.J. Grandy, G.A. Gómez-Ríos, J. Pawliszyn, G.A. Gomez-Rios, J. Pawliszyn, Development of a standard gas generating vial comprised of a silicon oil–polystyrene/divinylbenzene composite sorbent, J. Chromatogr. A. 1410 (2015) 1–8. doi:10.1016/j.chroma.

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